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Liposomal Curcumin Side Effects

Any time you are thinking about adding a supplement to your health regimen, it’s always a good idea to ask about side effects. In some cases, taking a supplement that you don’t know much about can cause more harm than good. Here’s an example. Awhile ago, I had some significant nerve pain. So I did some research and found three herbs that are supposed to reduce nerve pain and inflammation.

I took all three, and then I revisited the information, and discoverd to my surprise, that one of them can cause liver damage! Needless to say, I stopped using that particular herb.

Do you want to know what the liposomal curcumin side effects are? If yes, then you are in the right place. People should always ask questions of any supplement, whether turmeric, the source of curcumin, or liquid curcumin extract, or any other form of curcumin supplementation.

The overriding thing you need to know, is that curcumin, taken as a pill, capsule, liquid, or in particular liposomal curcumin is unlikely to have any ill effects, unless you take massive amounts. In any case, here are some of the side effects that are theoretically possible: stomach upset, nausea, vomiting if not taken with food or water; diarrhea; rash; itching; difficulty breathing or swallowing; chest pain; throat tightness; hives; inflammatory bowel disease. See below for details.

The human body has difficulty absorbing Curcumin in itself, so it may be chemically enclosed in the lipid phosphatidylcholine (LPC) to form liposomes or simply ‘curcumin-LPC.’

This allows the liposomal formulation of Curcumin to be easily absorbed and increases its bioavailability.

What is Liposomal Curcumin?

Curcumin is a compound that naturally occurs in the turmeric root and can be a supplement for inflammation caused by diseases, arthritis, oxidative stress, cancer, etc. You can find both liquid curcumin as well as liquid turmeric extracts.

It is lipophilic, meaning it likes to absorb fat; liposomal substances are composed of fat-loving molecules (lipids) that form tiny bubbles, which allow drugs to move through the stomach lining and dissolve in your blood.

Possible Adverse Effects of Using Liposomal Curcumin

What the World Health Organization Study Shows

While the adverse effects listed below are occasional phenomena, studies indicate that the FDA considers Curcumin even in large doses to be “GRAS” generally regarded as safe.

Curcumin has a long established safety record. For example, according to JECFA (The Joint United Nations and World Health Organization Expert Committee on Food Additives) and EFSA (European Food Safety Authority) reports, the Allowable Daily Intake (ADI) value of curcumin is 0–3 mg/kg body weight []. Several trials on healthy subjects have supported the safety and efficacy of curcumin. Despite this well-established safety, some negative side effects have been reported. Seven subjects receiving 500–12,000 mg in a dose response study and followed for 72 h experienced diarrhea, headache, rash, and yellow stool [](1)

  • Stomach upset

Some people experience stomach upset when taking Liposomal Curcumin. This can lead to nausea, vomiting, and diarrhea. If you’re one of the people who experience such an effect, it’s best to stop taking the supplement until you talk to your healthcare provider.

  • Nausea and vomiting 

Nausea and vomiting are the most common side effects of Curcumin, as they occur in 50% to 58% of people who take it.

  • Diarrhea

Diarrhea is a very common adverse effect of taking the supplement and can occur in up to 10% of patients. According to WebMD, diarrhea usually goes away on its own and should not be a cause for concern, but if diarrhea persists, you might want to talk to your doctor.

  • Rash or hives

Rash or hives are symptoms of allergic reaction to a medication. This can be an allergic reaction to the medication itself or an allergy to the inactive ingredients.

  • Itching or difficulty breathing or swallowing

Liposomal Curcumin can cause itching or difficulty breathing or swallowing. If you experience this, stop taking Liposomal Curcumin and talk to your doctor right away.

  • Chest pain

Chest pain can be caused by discomfort in the chest wall, heart disease, pulmonary disease, esophageal disorders, and lung disorders.

  • Throat tightness

Throat tightness is a symptom that many different factors can cause. It can be due to allergy, infection, stress, eating the wrong thing, or even exercising too hard.

Throat tightness may also happen if you have laryngopharyngeal reflux disease (GERD). This condition occurs when stomach acid leaks up into your throat, irritating.

The meal plan needs to be adjusted to make up for the lack of calories without feeling hungry. A lack of appetite can lead to more severe health problems such as heartburn and indigestion caused by overheating. Some of the leading causes of hives are allergic reactions to medication, other substances, or foods.

It’s essential for people who have had hives in the past to carry a card or wear a bracelet, telling others that they have been diagnosed with autoimmune diseases.

How to Take Liposomal Curcumin

It would help if you took Curcumin with food or water to be most effective, although taking it with milk has shown to decrease its effectiveness by about 25%.

Also Read:

Curcumin and Other Medicines or Foods

  • Taking curcumin supplements has the potential to reduce iron absorption
  • Curcumin may lower blood sugar levels, which could be dangerous if you take diabetes medications to increase your blood sugar.

To reduce the risk of side effects, you can split up your intake of Curcumin throughout the day (for example, taking 400mg three times a day).

Taking turmeric with black pepper has also been shown to increase curcumin absorption by up to 2,000%, however, if you take liposomal curcumin, which is absorbed in your intestine, black pepper is not needed.

Is liposomal curcumin safe?

Liposomal Curcumin is safe if used in moderate doses. Liposomal Curcumin was well tolerated, but a transient red blood cell echinocyte formation with a concomitant increase in mean cellular volume was seen at dosages of 120 mg/m2 or greater.

What is Liposomal curcumin used for?

Curcumin is an extract of the plant Curcuma longa. It is also known as turmeric. The extract has been used for many years for medicinal purposes. One of the main applications is inflammation reduction. It has also been found to have antioxidant properties.

There are many suggested ways to counter these side effects, but they need to be done with caution because they can make you sicker instead of helping with the side effects of taking liposomal Curcumin.

Liposomal Curcumin has many health benefits, including pain reduction, lower blood pressure, better gut health, and more.

Is liposomal curcumin better?

Liposomal Curcumin improves absorption by the body. Liposomes are tiny spheres that contain oil and water. They’re made of phospholipids which are arranged like bilayers in a soap bubble.

The molecules of liposomes become part of the phospholipid bilayer and, as a result, can be absorbed by cells in the body to deliver medicinal contents.

The main advantage of liposomal Curcumin is for people taking medicines that reduce their ability to absorb food and nutrients by decreasing stomach acid secretion and absorption rates.

Is Curcumin safe to take daily?

The World Health Organization (WHO) has established an acceptable daily intake of 1.4 mg per pound (0–3 mg/kg) of body weight.

Long-term use of high dosages of turmeric and Curcumin has not been studied. Therefore they are not recommended.


Liposomal Curcumin is effective in reducing inflammation and fighting cancer, but it may have some side effects. Make sure you take your dose with food or water if possible for the best results without any uncomfortable symptoms.

If you’re experiencing an adverse reaction from taking this supplement, stop immediately and consult with a doctor as soon as possible.

We hope this article has given you valuable insight on how to make an informed decision about whether or not liposomal Curcumin is suitable for you.

The information on this page is deemed reliable on a best efforts basis. However, it should only be seen for information, educational and entertainment purposes. It should not be taken as medical advice and this website assumes no liability. Always consult a medical professional before proceeding with any treatment.